No, you cannot scan negative strips and slides with this device. It is a flatbed scanner that is only designed for documents and photos.
To scan 35 mm negatives and slides, you need a specialised model such as the Epson Perfection V500 or V600.
Check that you have installed the latest Epson Scan 2 driver and software from the official Epson website, compatible with Windows 11. If the problem persists after the Windows update (as reported in similar cases with version 24H2), try the Microsoft Scan app that already works, or perform a Windows 11 repair by downloading the Media Creation Tool from the Microsoft website. Check the direct USB connection without a hub and restart the PC. If that doesn't solve it, consult Epson Support for specific assistance.
The Epson Perfection V39II (USB) scanner works perfectly with Windows 11 Home. Epson provides a driver and the Epson Scan 2 software that are compatible with Windows 11. This software can be downloaded from the Epson support page and allows the scanner to be used both wired and wirelessly.
However, there are reports from individual users who have had problems with the scanner being recognised under Windows 11, even though the official drivers are installed. In most cases, however, the scanner should work without any problems if the latest drivers and software from Epson are installed.
Following a request to Epson, it would appear that the only difference is in terms of compatibility. The V39II is compatible with the latest versions of macOS.