Yes, but you have to ask yourself whether it makes sense to spend 1500 for a graphics card but only 100 for the processor. in certain applications, you will notice that your cheaper processor will cut you off in terms of performance.
Actually, yes, if you make sure that the mainboard is not very old...but you should also make sure that the graphics card has enough space in the case and is not in the way of the hard drive cages, for example. And you should make sure that the power supply is guaranteed (sufficiently strong power supply unit).