I am using the ASUS ProArt PA279CV together with an iMac 27" 2019. The monitor is connected via a USB-C cable. The settings I made on the monitor yesterday were gone again today. How can I save the settings? In terms of colour, there is a big difference between the iMac and the Asus monitor. Can anyone tell me the optimum settings for the monitor? Thank you very much.

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As with other monitors that are connected via USB-C, various problems can occur. (The internet is full of them) Asus itself therefore says that this monitor is best connected to a Mac via Displayport.
I myself am not entirely enthusiastic about this solution, as the various USB ports of the monitor then no longer work at all.
I had the same problem, but have now connected the monitor via Displayport and calibrated it with a SpiderX. The settings are retained as they are saved on the computer. I'm not familiar with the settings provided on the monitor itself, but serious calibration is still best done with external hardware. 
Oh, and also digitec itself indicates that there are two video ports (including displayport) and one data port (the usb-c).

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Thank you for the answer. Unfortunately, my iMac 2019 doesn't have a Displayport port. So I would have to look for a Thunderbolt to Displayport adapter. Would that get me there?

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