Connected the USB stick with Knoppix version 8.6 Rel. 2019-10-14 to the Lenovo Travel Hub (HDMI, VGA, 45W, USB Type C, USB A), started the PC and selected the stick in the boot menu.
Started without problems.
HDD and USB sticks were connected and disconnected during operation without any problems.
The LAN connection also worked.
I did not test the VGA connection because I do not have a suitable cable.