Question about ASUS ProArt PA279CRV

Yes, the ProArt PA279CRV works well with a MacPro6.1 (Mac Pro 2013) using DisplayPort, HDMI or USB-C; USB-C also supports power and data but is not Thunderbolt.
Make sure to use a compatible cable/output (DisplayPort or USB-C) and check the DisplayPort OSD settings if you encounter recognition problems.

Important details:
- Supported connections: DisplayPort (2×) and HDMI (2×); USB-C port available for video and up to 96 W PD (not Thunderbolt).
- Resolution/refresh: UHD 3840×2160 at 60 Hz, compatible with Mac Pro 6.1 video outputs via DisplayPort or DisplayPort to Thunderbolt adapter.
- If using USB-C from newer Apple devices: DisplayPort Stream may need to be set to DisplayPort1.2 in the OSD in some cases.
- Multiple monitor compatibility: The ability to connect multiple monitors depends on the graphics capabilities and ports of the Mac Pro; check the maximum number of displays supported by your GPU configuration.

I'm not entirely sure if a specific macOS firmware/update is needed for your configuration; if you encounter problems, try
- update macOS and monitor firmware,
- use a direct DisplayPort cable or Thunderbolt adapter (mini-DisplayPort/DisplayPort port depending on your GPU),
- change the DisplayPort Stream setting on your monitor.