As far as I'm concerned, I have a Mac Mini M1 and I plugged the Focusrite directly into the USB and it works without any problems. I had a Focusrite of another generation (equivalent model) 10 years ago that I plugged into a 2013 iMac and the Plug&Play worked without a problem. For me it works perfectly and as long as your MacBook has a sound card capable of processing the information, I think it should be possible