On DX cameras (e.g. D500) this lens is excellent.
There are several test/review reports, e.g. https://photographylife.com/reviews/nikon-16-80mm-f2-8-4e-vr.
Conclusion - on DX : Highly recommended.
No, this is a Nikon lens for Nikon DSLRs. I wouldn't do it with an adapter either, it's never a satisfactory solution. Moreover, the 16-80 has an electronic aperture adjustment and no longer a mechanical one. That should dispel any belief that it will somehow work on a Canon camera.