Question about Lowepro ProTactic 450 AW

Yes, depending on which MacBook Pro 15" you have, this should fit. It is best to specify the exact model and/or year for Apple products. The older MacBook Pro 15" (before 2014 as far as I know) are too thick for this. The laptop compartment has the following dimensions, so you can judge for yourself right away: 37 x 28 x 2 cm