Hello Sandru, Yes it will. when you look at the ASUS ROG STRIX Z370-E GAMING specification you can see it requires a 24pin psu connection, and when you look at the spec of the psu you can see that it has a 24pin psu. I am a gaming systems builder, if you need any help, advise or have any questions regarding how to build an epic system, please get in touch. asidscript@gmail.com