Question about ASUS H110I-Plus S1151 H110 MITX

I also think that this is possible, at least I can't find anything in the motherboard description that speaks against it. However, considering the performance of this graphics card, I wonder if this board, which only supports 6th generation Core Intel CPUs, is really the right choice?

Yes, but PCI Express 3.0 is used and not PCI Express 4.0, as this mainboard does not support PCI Express 4.0.