The question of whether the product is compatible with an RTX 5080 graphics card depends on the specific connections required by the graphics card. The RTX 5080 requires at least three 8-pin PCI-Express cables and one 16-pin PCI-Express connection via an adapter. The product offers 8-pin and 16-pin PCI-Express connectors, making it potentially compatible as long as the cable lengths and connectors meet the requirements. It is advisable to check the exact specifications of the product and graphics card to ensure that all requirements are met.