Does anyone know if this card is compatible with the Asus z170 Pro Gaming motherboard? I heard that you have to pay attention to the connection (PCI or SATA) to ensure the speed...

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In short: Yes.

Long story:
I assume it's about "*1:When the M.2 Socket 3 is operating in SATA mode, SATA port 1 will be disabled."
In other words, if a component with SATA protocol is installed in the M.2 slot, you lose the SATA ports.

This SSD uses NVMe with PCIe, so no problem. (Samsung product page under More Specs: "INTERFACE: PCIe Gen 3.0 x4, NVMe 1.3).

For more information on PCIe and SATA in M.2: https://www.crucial.com/articles/about-ssd/m2-with-pcie-or-sata
For more information on PCIe: https://de.wikipedia.org/wiki/PCI_Express
For more information on SATA: https://de.wikipedia.org/wiki/Serial_ATA

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Does anyone know if this card is compatible with the Asus z170 Pro Gaming motherboard? I heard that you have to pay attention to the connection (PCI or SATA) to ensure the speed...